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ea0077oc6.1 | Thyroid | SFEBES2021

Adjuvant Rituximab – exploratory trial in young people with Graves’ disease

Cheetham Tim , Cole Michael , Abinun Mario , Alalhabadia Amit , Barratt Tim , Davies Justin , Dimitri Paul , Drake Amanda , Mohamed Zainaba , Murray Robert , Steele Caroline , Zammitt Nicola , Carnell Sonya , Prichard Jonathan , Watson Gillian , Hambleton Sophie , Matthews John , Pearce Simon

Objective: Remission rates in young people with Graves hyperthyroidism are <25% after a 2-yr course of thionamide antithyroid drug (ATD). Immunomodulatory agents might improve outcome by facilitating immune tolerance. We explored whether rituximab (RTX) would increase remission rates when administered with a short course of ATD.Design: This was an open label multi-centre single arm phase 2 trial in newly presenting young people (12-20y) with Gr...

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Adjuvant Rituximab – exploratory trial in young people with Graves’ disease

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